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When Measurement Conventions Masquerade as Calibration Gains in Cardiac Digital Twins
US & West ·
This paper shows that apparent calibration improvements in cardiac digital twins may be artifacts of measurement conventions. Comparison of four models on a shared backbone revealed that CAMUS bias removal is explained by a +6.30 point difference between single-plane and biplane ejection fraction measurements, not by actual improvement. Replicating EchoNet-Dynamic with extractor aligned to the apical four-chamber plane removed overestimation and reversed the ranking.
Why it matters
Highlights the importance of rigorous validation and consideration of measurement conventions when evaluating models, which is critical for the reliability of digital twins in medical and industrial applications.
Original headline
When Measurement Conventions Masquerade as Calibration Gains in Cardiac Digital Twins
Growing interest in in-space servicing, manufacturing, and assembly has renewed attention on reliable metal joining for modular construction and on-orbit repair. Robotic welding is promising, but reduced-gravity and low-pressure operation remains poorly characterised and flight-like tests are…
Digital twins (DTs) can generate dense synthetic fingerprints for localization via ray tracing, yet the sim-to-real domain gap limits their direct use, particularly in cell-free millimeter-wave (mmWave) deployments where distributed geometries and blockage-induced sparsity widen the mismatch.
Catheter obstruction is the commonest cause of shunt failure; freehand insertion at Keen's point leaves the tip free in cerebrospinal fluid in only one case in ten. We built a digital twin that reconstructs skull, scalp, ear and ventricles from preoperative CT by deterministic geometry, searches…
